A 70 year old man has been taking Bendroflumethiazide for hypertension for many years. A recent routine blood test revealed a moderate neutropenia, thrombocytopenia and raised alkaline phosphatase level. Subsequent investigation has shown a monoclonal gammopathy with no evidence of myeloma or other serious pathology. Could the BFZ be implicated in these findings?
Hematologic side effects from bendroflumethiazide are rare. Rare cases of immune-complex hemolytic anemia, aplastic anemia, and thrombocytopenia have been associated with thiazide diuretics.
Read more: https://www.drugs.com/sfx/bendroflumethiazide-side-effects.html#ixzz0wFRAFA1z
Monoclonal gammopathy of undetermined significance (MGUS) is a blood disorder that occurs when there is overgrowth of identical plasma cells in bone marrow. Since it is the job of any given plasma cell to make a single (monoclonal) immunoglobulin protein, an increased population of identical bone marrow plasma cells may be detected by discovery of a monoclonal protein (M protein) in the blood stream. Rarely, MGUS can be a precursor to cancer, such as multiple myeloma, or other serious blood disorders. But for most people, MGUS is harmless and doesn't cause symptoms or require treatment.
MGUS is a common condition that becomes more prevalent with age. About 3 percent of people 50 and older and 5 percent of those 70 and older have M protein in their blood. The highest incidence is among adults age 85 and older. And MGUS is more common in men than in women.
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