Skip to Content

Is there a difference between Zoloft and its generic? I have just started on Sertraline 25 mg?

Question is Closed
Report Favorite

Answers (4)

20 Aug 2011

There could be a difference big enough that would affect you. I've heard that Generics just have to be within 20 percent of the amount of the active ingredient. I don't know about you, but taking up to one-fifth less on the dosage can be enough to feel differently. That's not to say that each generic is 20% less - just that in can be UP to that amount. Also every medication has fillers, preservatives, binders, caulking agents, dyes, etc in the inactive ingredients - even in the brand name. Based upon your body and how it functions, allergies you might have, etc the medication could absorb differently. If you detect a huge difference you may need to ask your doctor to specify brand Name Necessary on your prescriptions. Best wishes -

Votes: +1

20 Aug 2011

Marybeth - I was on both in past years on two seperate occasions, and saw no difference. Both were able to accomplish what I was prescribed them for. Hope this helps.

Votes: +1
booter46 20 Aug 2011

I too have seen no difference. But generics are different and could effect you different than me. I am sorry I do not have a better answer.

20 Aug 2011

Hello marybeth23! I have been on both. I have also been on Sertraline for years now. I was previously on Zoloft. I have never noticed any difference. I know Sertraline is cheaper. I really do not think there is much difference but you can try Sertraline and see if it works for you. I wish you the best! Sweetie Pie

Votes: +0

20 Aug 2011

No difference at all. Sertraline HCL is Zoloft, Zoloft is just the trade name, which is what you end up paying big bucks for. ;)

Votes: +0

Further Information

Search for questions

Still looking for answers? Try searching for what you seek or ask your own question.

Similar Questions

I think I have been given generic Zoloft. It is not working as well... is the generic as good?

I have been taking Zoloft or Sertraline (150 mg daily) for about 7 yrs now. It has worked very well until recently. My last prescription refill the ...

2 answers 24 Aug 2010

Does anyone know why generic Zoloft was a $ 4.00 medicine and now it is not?

I have been getting my Sertraline HCL at the same drug store for 6 months now and I have been paying $ 4.00 because it was on the $ 4.00 list. This ...

1 answer 10 May 2011

Weaning off of Sertraline (aka Zoloft)?

Hi everyone. I am new to the forums and have a very important question. I am planning to wean off of my SSRI, Sertraline (generic of Zoloft). I have ...

3 answers 7 Feb 2013

Is Cymbalta worth it?

Hey everyone, I was just prescribed Cymbalta for depression/anxiety after taking the Zoloft generic, setraline for a little less than three months. ...

4 answers 8 days ago