My friend is 26 wks. prgnant and has sinus infection, her Dr. prescribed prednisone 10mg. Is this completely safe for the fetus?
Your friend and her doctor needs to weigh the risks verses benefits of taking prednisone during her pregnancy.
This is the information available:
Prednisone Pregnancy Warnings
Prednisone has not been formally assigned to a pregnancy category by the FDA. However, its active metabolite, prednisoLONE, has been assigned to pregnancy category C by the FDA. Some animal studies have revealed evidence of fetal harm, although data are conflicting. There are no controlled data in human pregnancy. Prednisone is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.
In the Michigan Medicaid Birth Defects Study involving 229,101 pregnancies from 1985 to 1992, there were 143 first trimester exposures to prednisolone (written communication, Franz Rosa, MD, Food and Drug Administration, 1994). A statistically significant increase in the total number of birth defects was found, with eleven cases reported compared with only six cases expected. However, no association between prednisolone and the six categories of defects studied (cardiovascular, oral clefts, spina bifida, polydactylies, limb reduction defects/syndactylies, hypospadias) was found.
- Prednisone Information for Consumers
- Prednisone Information for Healthcare Professionals (includes dosage details)
- Side Effects of Prednisone (detailed)
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