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Is it safe to take ativan seroquel and flexoral?

Responses (2)

BRRMARS 24 Apr 2011

they are combatible just watch for the following.

MANAGEMENT: Caution is advised when agents with anticholinergic properties are combined, particularly in the elderly and those with underlying organic brain disease, who tend to be more sensitive to the central anticholinergic effects of these drugs and in whom toxicity symptoms may be easily overlooked. Patients should be advised to notify their physician promptly if they experience potential symptoms of anticholinergic intoxication such as abdominal pain, fever, heat intolerance, blurred vision, confusion, and/or hallucinations. Ambulatory patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them. A reduction in anticholinergic dosages may be necessary if excessive adverse effects develop.

i hope this was helpful is so please answer yes this answer was helpful.

your friend

LaurieShay 24 Apr 2011

Hey jenjen,

Just to add to what BRRMARS shared, the interactions checker says the following:

lorazepam ↔ cyclobenzaprine
Applies to: Ativan (lorazepam), Flexeril (cyclobenzaprine)

MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

lorazepam ↔ quetiapine
Applies to: Ativan (lorazepam), Seroquel (quetiapine)

MONITOR: The oral clearance of a single dose of lorazepam has been reported to be decreased by 20% when taken concomitantly with quetiapine. The mechanism of action is unknown. Additionally, quetiapine may enhance the CNS effects of lorazepam.

MANAGEMENT: The clinician may consider closer clinical monitoring of the patient for lorazepam toxicity if quetiapine and lorazepam are coadministered. Patients should be advised to notify their physician if they experience symptoms such as excessive sedation, confusion, dizziness, or incoordination.

cyclobenzaprine ↔ quetiapine
Applies to: Flexeril (cyclobenzaprine), Seroquel (quetiapine)

MONITOR: Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) may have additive effects when used in combination. Excessive parasympatholytic effects may result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention, and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy, and seizures. Central nervous system-depressant effects may also be additively or synergistically increased when these agents are combined, especially in elderly or debilitated patients. Use of neuroleptics in combination with other neuroleptics or anticholinergic agents may increase the risk of tardive dyskinesia.

MANAGEMENT: Caution is advised when agents with anticholinergic properties are combined, particularly in the elderly and those with underlying organic brain disease, who tend to be more sensitive to the central anticholinergic effects of these drugs and in whom toxicity symptoms may be easily overlooked. Patients should be advised to notify their physician promptly if they experience potential symptoms of anticholinergic intoxication such as abdominal pain, fever, heat intolerance, blurred vision, confusion, and/or hallucinations. Ambulatory patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them. A reduction in anticholinergic dosages may be necessary if excessive adverse effects develop.

If you have any symptoms mentioned above please contact the doctor asap.

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