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Is it right to double Tamiflu dose in high risk patients? and what if they have renal impairment?

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suzanne66 31 Jan 2010

Are you wanting to take Tamiflu as a preventative?
If so this applies from

"... The recommended oral dose of Tamiflu for prophylaxis of influenza in adults and adolescents 13 years and older following close contact with an infected individual is 75 mg once daily for at least 10 days. Therapy should begin within 2 days of exposure. The recommended dose for prophylaxis during a community outbreak of influenza is 75 mg once daily. Safety and efficacy have been demonstrated for up to 6 weeks. The duration of protection lasts for as long as dosing is continued."

There is no recommendation to double the dose in high risk patients.
Dose adjustment will be needed if serum creatinine clearance <30 mL/min free discount card

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