It is possible. Effexor and Pristiq are very similar in chemical formula. In fact, Pristiq is like an improved version of Effexor with less side effects. I have been on both of these medications. I don't recall whether I gained weight while on Effexor, but I have lost weight while taking Pristiq. That being shared, I have been very careful what I eat and make sure the calories burned are greater than the calories consumed, thus I suspect my weight loss has been a matter of reduced calories. Although the Pristiq has helped motivate me to want to lose the weight.
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