Diabetes 2. I was switched to glyburide 2 years ago. This is the only medication that I am on. Over the last couple of years, I've developed foot problems, extremely painful all the time from the ankles down with ever increasing intensity. Last year I could walk it off and overcome it... now I cannot even pinpoint where the worst pain is. I use really good shoes and change them 10-15 times daily. They are so painful that I feel like I walk like a slow duck, thus almost no excercise anymore. Is it at all possible that the glyburide (only medication I am on) has an accumulation effect and could be causing this?