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Is it okay to take doxepin and atarax together?

Responses (1)

Anonymous 22 Dec 2011

Hello,

I would discuss the following " Moderate" - ("Moderately clinically significant. Usually avoid combinations; use it only under special circumstances".) interaction with your Dr. before using both medications (atarax which is a sedative with doxepin which is a hypnotic as you know) , to see if the benefits outweigh the risks involved:

Interactions between your selected drugs

doxepin ↔ hydroxyzine
Applies to: doxepin, Atarax (hydroxyzine)
MONITOR: Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) may have additive effects when used in combination. Excessive parasympatholytic effects may result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention, and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy, and seizures. Central nervous system-depressant effects may also be additively or synergistically increased when these agents are combined, especially in elderly or debilitated patients. Use of neuroleptics in combination with other neuroleptics or anticholinergic agents may increase the risk of tardive dyskinesia.

MANAGEMENT: Caution is advised when agents with anticholinergic properties are combined, particularly in the elderly and those with underlying organic brain disease, who tend to be more sensitive to the central anticholinergic effects of these drugs and in whom toxicity symptoms may be easily overlooked. Patients should be advised to notify their physician promptly if they experience potential symptoms of anticholinergic intoxication such as abdominal pain, fever, heat intolerance, blurred vision, confusion, and/or hallucinations. Ambulatory patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them. A reduction in anticholinergic dosages may be necessary if excessive adverse effects develop.

Other drugs that your selected drugs interact with

doxepin interacts with more than 500 other drugs.
Atarax (hydroxyzine) interacts with more than 300 other drugs.

Interactions between your selected drugs and food

No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.

https://www.drugs.com/interactions-check.php?drug_list=935-0,1303-774

All the best,

maso.-

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