I have been on Fluoxetine for about 5 years with only 3-6 month break in 2008 however after being on 2 per day for nearly a year, I was feeling very down, lethargic, wanted to hybernate, teary and my GP decided it was time to try something else but while in my second weak off weaning on 1 per day i was feeling much better and now i dont take any and get out of bed easier and feel im sleeping slightly better too