it can br a dangerous mix depending on a persons tolerance and dosage. methadone has a long half life uo to 72 hours where xanax is short lived up to 8 hour. if you are under a doctors care i would not go above 4mg of xanax a day and 60mg of methadone if u are even tolerant. its tricky because both deress the respiratory system. alot of er admitts are because of this combo. the antidepressant is usually safe especiallt the newer ones. the simi is used for hbp or cholesteral, i forget, if for bp becareull if for choleseral u should be fin, please give more info dosage,how long on them and for what symptoms, that will be helpfull
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