My glaucoma meds have been adjusted. Due to reactions to Alphagan, it was discontinued and the Cosopt I was also using with the Alphagan was increased from 2 to 3 X daily, and overall I felt so much better. My blood pressure leveled out, I had more physical strength and was more alert. Doctor concerned this was too much Cosopt for my heart, so dropped it and I now have Lumigan x1, Istalol x1 and Azopt x3, but I have experienced loss of physical strength and mental clarity, and bp not as consistent as during short time I was on only Cosopt..