... on 3 different antibiotics as i was told its a UTI. I am now on naproxen, amytriptyline, and antihistamine (loratedine), None of these have worked, I've been on them a week and a half. I am drinking lots of water to flush the system. I have a lot of pressure on my bladder and pubic bone area all the time, very uncomfortable and very frequent urinating. (no burning or stinging). Any advise i'm desperate for it to go as its taking over my life :(?