I have been on 50 mg dosage of Zoloft for upwards of 7 years now. Recently I made some faulty life choices that have spiraled me into crippling anxiety. I am pretty sure that I need a higher dosage of Zoloft as well as counseling. My question is-does dosage of Zoloft lose effect after so long? Will a higher dosage help me? Hopefully going to the doctor tomorrow.