In April 2011, I started 30 units of Lantus before bed in addition to my many-year use of 1000mg metformin b.i.d. and glyburide 2mg b.i.d. Morning sugars are finally normal (90-110). In late June, I started suffering horrific leg cramps through the night. My doc recommended tonic water (w/quinine) after dinner. It works, but only if I drink a minimum of 32 ounces. So now I'm up during the night peeing myself silly. Funny thing... I forgot to take my Lantus the other night and slept through the night without a single issue. Doc doesn't know or seem to care. Any thoughts?