I am a 48 year old female with a history of depression. Been on a slew of drugs (Prozac, Zoloft, Cymbalta, Effexor and most recently, 120mg of Fetzima with 15mg of Abilify. I have lost two children due to a rare metabolic storage disorder (my only kids) so not only is it depression, it is grief. I find that after being on these drugs for awhile, that I just become immune and the depression is just as bad so like an idiot, I stop taking them. The depression has gotten really bad again (not wanting to leave the house/shower) so I saw a new psych today who prescribed 50mg for imipramine for the first 5 days and then I increase to 100mg after that -- just 1x a day. Not that I am happy about the side effects that I am reading (oh joy - weight gain) -- but I have been doing my googling aoub the drug and see on various message boards about the negative effects of this drug. Has anyone truly gotten rid/improved their depression with Imipramine? Thanks