I try to take it at 6:30 daily part of my morning routine. On the weekends, I forget to take it at that time and will take it later in the morning. I don't miss a whole day without taking one. Yesterday I took it at 8:30 am and today because of the time change, I took it an hour earlier. I've read the dosage info and what to do if you miss a pill but am a little confused if taking it an hour or two later or earlier makes that big of a difference since the directions say to take the same time each day. Anyway, if someone could answer, I'd appreciate it. I have a feeling i'm being to obsessive.