Iv stared taking them for my hand about 2-1/2 years ago,i use to take about 60-65 mgs aday and that was 30mgs in the morning and 20 more 3-4 hours latter and 15 and a 1mg kped 2-3 haurs befor bed... But like a mounth ago i found my self taking higher doses its geting where they ant doing anything anymore and im scard my tolerance is why to high any way to stop that too...