Coreg CR should be used with cation in liver disease eg Hepatitis. In some sites I have visited it is contraindicated in severe liver disease.
No studies have been performed with COREG CR in patients with hepatic impairment. Compared to healthy subjects, patients with cirrhotic liver disease exhibit significantly higher concentrations of carvedilol (approximately 4- to 7-fold) following single-dose therapy with immediate-release carvedilol.
Check with your doctor.
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