If you mean will it keep other pain meds from working , no, not like something such as Suboxone will but use of other opiates with methadone needs to be monitored because of the risk of central nervous system and respiratory depression. The following warning accompanies the use of methadone with something like oxycontin:
methadone ↔ oxycodone
Applies to: methadone, OxyContin (oxycodone)
MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.
MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
So do not take more than prescribed. If it isn't prescribed please do not do it, CNS and respiratory depression can land you in a coma or even worse.
- OxyContin Information for Consumers
- OxyContin Information for Healthcare Professionals (includes dosage details)
- Side Effects of OxyContin (detailed)
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