I take Fosamax and must remain upright during that wait due to possibility of esophageal irritation, but it's only 1/2 hour and once a week. Waiting an hour daily is a burden. I usually go to the bathroom just before dawn and go back to bed until the alarm rings. I could set the capsule out the night before and take it then if would not cause a problem. On the day I take Fosamax, I wait and take the Sanctura 1 hour before lunch. Thanks. Nan, age 77.