Interactions between your selected drugs
ciprofloxacin ↔ ibuprofen
Applies to: ciprofloxacin, Advil (ibuprofen)
MONITOR: Coadministration with nonsteroidal anti-inflammatory drugs (NSAIDs) may potentiate the risk of central nervous system toxicity sometimes associated with fluoroquinolone use. The interaction has been reported most often with enoxacin. It may occur with other fluoroquinolones as well, but is poorly documented. The exact mechanism of interaction is unknown. Some investigators suggest that the piperazine ring of fluoroquinolones may inhibit the binding of gamma-aminobutyric acid (GABA) to brain receptors and that NSAIDs may synergistically add to this effect. Patients with a history of seizures may be at greater risk.
MANAGEMENT: Clinical monitoring for signs of CNS stimulation such as tremors, involuntary muscle movements, hallucinations, or seizures is recommended if fluoroquinolone antibiotics are prescribed in combination with NSAIDs.
Other drugs that your selected drugs interact with
ciprofloxacin interacts with more than 300 other drugs.
Advil (ibuprofen) interacts with more than 200 other drugs.
Interactions between your selected drugs and food
ciprofloxacin ↔ food
Applies to: ciprofloxacin
ADJUST DOSING INTERVAL: Concurrent ingestion of dairy products (milk, yogurt) or calcium-fortified foods (i.e., cereal, orange juice) may decrease the activity of certain oral fluoroquinolone antibiotics. The mechanism is chelation of calcium and the quinolone, resulting in decreased bioavailability. In the case of orange juice, inhibition of intestinal transport mechanisms (P-glycoprotein or organic anion-transporting polypeptides) by flavones may also be involved. One study reported an average 41% decrease in maximum plasma concentrations and a 38% decrease in AUC when ciprofloxacin was given with calcium-fortified orange juice instead of water.
MANAGEMENT: Dairy products or calcium-fortified foods should be ingested at least 2 hours after or 6 hours before fluoroquinolone administration.
I suggest you discuss this interaction with your Dr.-
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