heart attack in 2003 and I found some medical records that say,Mutation in other genes or other mutations in the factor V gene that may cause APC resistance and venous thrombosis,are not ruled out.Patient DNA was assayed for the Arg%)^Glu Leiden mutation in the factor V gene by polymerase chain reaction (pcr),and fluorescence monitoring using hybridization probes. Sensitivity and specificity for detection of this mutation is 99.9 percent. My question is do you think it is safe to take evista? Also My feet are bruising pretty bad on top,do you know what could cause this? thank You.