The lisonopril makes me feel severely depressed and lithargic, I can not tollerate the side effects. The combination is not decreasing the blood pressure rate and I have pleaded with my doctor to try a new combination ( he is forcing me to stay on the lisonopril because he thinks I will adjust to the side effects, when in fact I am considering to just stop taking the med. What might be a substitute for the lisonopril that does not have the side effects of tiredness, muscel weakness and depression.