... been on this meds. Everything I am on is proscribed by the same dr.or couple drs. They know what meds I am on because I always give them a paper with all my meds listed. I am on: fluoxetine, isosorbide, amitriptyline,metoclopramide,metoprolol, simastatin,k-dur,lasix, levothroid , plavix,risperidone as well as lantas and aspirin multivitam, centrum silver w/vit.d, high potency b complex and chromium picolite I am 58 yrs. old ,female and have diabetics as well as having had a heart attack last nov. and I have also had the gastric bypass surg. (runy type of gastric bypass) I also lost my entire right breast to cancer 10 years ago. I am still having problems with my bypass so anyone that wants to chat with me about it give me a yell! Thanks so much ! By the way I put all my meds into the interaction part of Drugs .com and there are so many reactions I can't figure out how to take them without reactions !! Please help me !! ==Wanda fr. NC==
Hello fitby60/Wanda. Welcome. You are in the right place. Lots of support, good things, from many good people. Ha! You've certainly gone through the gaunlet so to speak. I hope that you some comfort within this site. I can relate very much so, to depression, the anxiety that I know often comes, along with it. I was on zoloft, some years ago, prozac came on the market not long after zoloft, so I know the drug family. I dropped the zoloft, it worked against my being able to sleep. I suffer from insomnia. ha! I was on Elavil, also, some years ago. Helped me to sleep however I also built up an immunity to it, so, that was dropped. I can go on, a trade mark of mine, (talk up a storm) :-0) Once again, hoping you find some of your answers in this site. Best wishes,
I would be most concerned about the major interactions first which involve the following:
fluoxetine and plavix (clopidogrel)
MANAGEMENT: Based on existing data, patients treated with clopidogrel should avoid the concomitant use of drugs that are inhibitors of CYP450 2C19 such as omeprazole, cimetidine, delavirdine, efavirenz, etravirine, felbamate, fluoxetine, fluvoxamine, fluconazole, isoniazid, ketoconazole, letrozole, moclobemide, modafinil, oxcarbazepine, ticlopidine, and voriconazole
amitriptyline and K-dur
MANAGEMENT: The use of oral solid formulations of potassium chloride is considered contraindicated in patients receiving agents with anticholinergic properties at sufficient doses to exert anticholinergic effects. A liquid formulation of potassium chloride should be considered. Patients prescribed a solid oral formulation should be advised to discontinue potassium therapy and contact their physician if they experience potential symptoms of upper GI injury such as severe vomiting, abdominal pain, distention, and gastrointestinal bleeding.
metoclopramide and risperidone
MANAGEMENT: Due to the potential for increased risk of serious and potentially irreversible extrapyramidal reactions, metoclopramide should not be prescribed in combination with other antidopaminergic agents. In addition, metoclopramide should not be used for longer than 12 weeks except in rare cases where therapeutic benefit is anticipated to outweigh the risk of developing tardive dyskinesia.
amitriptyline and fluoxetine
MANAGEMENT: In general, the use of fluoxetine (or other SSRIs) with TCAs should be avoided if possible, or otherwise approached with caution if potential benefit is deemed to outweigh the risk. Pharmacologic response and plasma TCA levels should be monitored more closely whenever fluoxetine is added to or withdrawn from therapy in patients stabilized on their existing antidepressant regimen, and the TCA dosage adjusted as necessary. Patients should be monitored closely for signs and symptoms of TCA toxicity (e.g., sedation, dry mouth, blurred vision, constipation, urinary retention) and/or excessive serotonergic activity (e.g., CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia). Due to the long half-life of fluoxetine and its active metabolite, norfluoxetine, the risk of interaction may persist for several weeks after discontinuation of fluoxetine.
With the above interactions, I would be most concerned about the fluoxetine and plavix. It is not a recommended combination. The amitriptyline/K-dur interaction can be avoided by switching to a liquid potassium chloride solution. The metoclopramide with resperidone is a a potentially risky combination and the metoclopramide should not be prescribed longer than 12 weeks. The amitriptyline with fluoxetine requires paying attention to the symptoms of TCA toxicity and excessive serotonergic activity.
If I were you, I would contact the prescribing doctor and discuss these interactions with him/her. The remaining interactions are moderate and manageable with appropriate monitoring of blood glucose levels and blood pressure.
I know this is overwhelming ot say the least, but just take it one step at a time and get your doctor to discuss these issues with you. If he won't then I would consider having another doctor such as an internist evaluate the medications you are on.
Hi, I am so sorry to hear about all your health problems. All drugs have side effects. Your doctors need to talk to you about all and any side effects that you may or may not get,it is thier job to moniter and tell you what you may expect. Some doctors just hand the pills out without telling people what could happen. That is wrong and it happen to me. You need to get answers and you are entiled to them. This is your body. If they have a problem with that, than I would find another doctor. I don't know too much about all the drugs you are on. If you go onto web MD it will tell you about any drug. Some medication you do need, but sometimes doctors can over medicate. I am not saying your doctors are doing that, but it has happen to me and other people I know. Learn to ask questions that is your right. I hope in some way this has helped and if you need to talk I am here for you. Take care and I hope things get better. This is a great web site. I have talked to many people and it has helped me a lot. We all do care. Let me know how you are doing.
I agree with all the answers here and the only advice that i can add is for you to educate yourself on the potential side affects. As everyone has said most drugs either have or could have side affects. My doctor tells me that those side affects may not show up right away but could anytime after continuous use. Therefore its important that you monitor yourself for those and if you are experiencing them tell your doctor right away. Your doctor will know if the side affects are normal and acceptable or in need of attention. With your health issues you should make sure you have a doctor that is easily accessed. Also, do not hesitate to go to emergency if you experience severe symptoms. I wish you the best, Paddyanne47
- Fluoxetine Information for Consumers
- Fluoxetine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Fluoxetine (detailed)
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