It really wasn't too much of a surprise since my blood pressure readings have been high for quite some time and also it runs in my family. What has me baffled is the list of drug interactions with this drug ( HCTZ for high blood pressure )!!! WOW ! this drug literally interacts with practically everything. So what does one take for a headache when i see that Advil , ibuprofen, acetaminophen, tylenol , they all have interactions ? And what about for heartburn? I see that even Tums has an interaction... I am really confused and worried about this . i guess i had no idea of this or i would have asked my doctor before i left the office . Any help would be GREAT . thanks