Enbrel caused large red whelks on my breast and a painful knot on my knee that is still there after discontinuing four months ago.Muscle pain in my legs and arms developed and have also continued. I've had both my hips replaced and was doing well with them until I tried the enbrel. I now have pain in the tissue and ligaments and muscles surrounding the new hip joints. The psoriasis did improve a little but has come back with a vengeance. I had such high hopes that the enbrel would stop the progression of ankylosing spondalitis in my spine but I guess I'll only get worse. My doctor said we could try Humira but he didn't reccommend it for me. I pray for a cure. Has anyone else had the problems I've experenced?