I am having the Xanax reduced so I can stop it completely. I have been on the Zoloft for about 3 months now, and just today have been given the thyroid medicine.
Interactions between your selected drugs
alprazolam ↔ sertraline
Applies to: Xanax (alprazolam), Zoloft (sertraline)
Sertraline may increase plasma alprazolam concentrations by inhibiting its CYP450 3A4 metabolism. In healthy subjects, there were no pharmacokinetic changes and there were slight decreases in a driving simulation test score. The clinical significance is believed to be minor.
No other interactions were found between your selected drugs.
Note: this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
Other drugs that your selected drugs interact with
levothyroxine interacts with more than 100 other drugs.
Xanax (alprazolam) interacts with more than 300 other drugs.
Zoloft (sertraline) interacts with more than 300 other drugs.
Interactions between your selected drugs and food
alprazolam ↔ food
Applies to: Xanax (alprazolam)
GENERALLY AVOID: The pharmacologic activity of oral midazolam, triazolam, and alprazolam may be increased if taken after drinking grapefruit juice. The proposed mechanism is CYP450 3A4 enzyme inhibition.
MANAGEMENT: The manufacturer recommends that grapefruit juice should not be taken with oral midazolam. Patients taking triazolam or alprazolam should be monitored for excessive sedation. Alternatively, the patient could consume orange juice which does not interact with these drugs.
levothyroxine ↔ food
Applies to: levothyroxine
ADJUST DOSING INTERVAL: Consumption of certain foods as well as the timing of meals relative to dosing may affect the absorption of T4 thyroid hormone (i.e., levothyroxine). T4 absorption is increased by fasting and decreased by foods such as soybean flour (e.g., infant formula), cotton seed meal, walnuts, dietary fiber, calcium, and calcium fortified juices.
MANAGEMENT: Preparations containing T4 thyroid hormone should be administered on a consistent schedule with regard to time of day and relation to meals so as to avoid large fluctuations in serum levels. Foods that may affect T4 absorption should be avoided within several hours of dosing if possible.
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