I also take Xanax and Seroquel as needed in a crisis. I have Dysthemia (chronic low mood) with periodic bouts of Major Depression. I also have anxiety and mild OCD. I had a hysterectomy about the same time I started using anti-depressants. I have gained almost 50 lbs over the years. Has anyone else experienced weight gain on Celexa and has anyone had success losing weight while on it?