I just went on tri-sprintec in January (after being off of the pill for about 5 years and 2 kids). I am on my 3rd pack and I am soo moody I can't even stand myself. I came to this site to see if I could find out if anyone had the same side effects and if so if they knew of a pill that had a lower dosage of hormones. I used to take ortho tri-cyclen lo years ago and I dont remember feeling this way. I would still take the ortho tri cyclen lo but it is $70 a pack and there is no generic for it. This isn't worth it. I can't even stand myself.