Presently i take 250mg. twice a day. What would you recommend as a dosage of for Phenobarbital?
I hear that Primidone is being taken off the market?
Added 2 Jul 2011:
It is my pharmacist that is recommending Phenobarbital. BTW should I also include Depakote... one of the drugs that Primodone breaks up into?
Added 2 Jul 2011:
I am 55 years old and weigh about 205 lbs.
Primidone has probably not been taken off the market, however please do double check it a pharmacist.
Suggested doses of phenobarbital for specific indications are as follows:
a. Pediatric Oral Dosage (as recommended by the American Academy of Pediatrics):
Preoperative: 1 to 3 mg/kg.
b. Adult Oral Dosage:
1. Daytime sedative: 30 to 120 mg daily in 2 to 3 divided doses.
2. Bedtime hypnotic: 100 to 320 mg.
3. Anticonvulsant: 50 to 100 mg 2 to 3 times daily.
Dosages of phenobarbital must be individualized with full knowledge of their particular characteristics and recommended rate of administration. Factors of consideration are the patient's age, weight, and condition. Parenteral routes should be used only when oral administration is impossible or impractical.
Anticonvulsant use: A therapeutic anticonvulsant level of phenobarbital in serum is 10 to 25 µg/mL. To achieve the blood levels considered therapeutic in children, higher per-kilogram dosages are generally necessary for phenobarbital and most other anticonvulsants. In children and infants, phenobarbital at loading dose of 15 to 20 mg/kg produces blood levels of about 20 µg/mL shortly after administration.
In status epilepticus, it is imperative to achieve therapeutic blood levels of phenobarbital as rapidly as possible. Because a barbiturate-induced depression may occur along with a postictal depression once the seizures are controlled, it is important, therefore, to use the minimal amount required, and to wait for the anticonvulsant effect to develop before administering a second dose.
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