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I have ED. I want to try sildenafil. How long should I stop isosorbide Mono ER b4 taking sildenafil?

Answers (1)

28 Jul 2010

The use of PDE5 inhibitors by patients receiving organic nitrates or other nitric oxide donors, either regularly or intermittently, is considered contraindicated. A suitable time interval following administration of sildenafil or vardenafil for the safe administration of nitrates has not been determined. For tadalafil, data from a clinical pharmacology study suggest that at least 48 hours should elapse after the last dose of tadalafil before nitrate administration is considered should it be deemed medically necessary in a life-threatening situation. Even then, nitrates should still only be administered under close medical supervision with appropriate hemodynamic monitoring.

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In case of Sildenafil, would recommend that you seek more professional advice from the doc/pharmacist who prescribed the meds, hope the info is of use to you?

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