I eat a 1/2 grapefruit every morning. Is this OK with Losartan?
Interactions between your selected drugs and food
losartan ↔ food
Applies to: losartan
GENERALLY AVOID: Moderate-to-high dietary intake of potassium, especially salt substitutes, may increase the risk of hyperkalemia in some patients who are using angiotensin II receptor blockers (ARBs). ARBs can promote hyperkalemia through inhibition of angiotensin II-induced aldosterone secretion. Patients with diabetes, heart failure, dehydration, or renal insufficiency have a greater risk of developing hyperkalemia.
MANAGEMENT: Patients should receive dietary counseling and be advised to not use potassium-containing salt substitutes or over-the-counter potassium supplements without consulting their physician. If salt substitutes are used concurrently, regular monitoring of serum potassium levels is recommended. Patients should also be advised to seek medical attention if they experience symptoms of hyperkalemia such as weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs.
MONITOR: Grapefruit juice may modestly decrease and delay the conversion of losartan to its active metabolite, E3174. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The clinical significance is unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.
MANAGEMENT: Patients who regularly consume grapefruits and grapefruit juice should be monitored for altered efficacy of losartan. Grapefruits and grapefruit juice should be avoided if an interaction is suspected. Orange juice is not expected to interact.
All the best and take care.-
So, in other words, continuing on from maso, if you have always had a grapefruit every morning and your blood pressure is controlled, and you have no side effects, then it is safe for you to continue.
Certain chemicals that grapefruit contain can interfere with the enzymes that break down (metabolize) various medications in your digestive system.
As a result, more medication stays in your body. This can increase the potency of your medication to potentially dangerous levels, causing serious side effects. Calcium channel blockers are an example of a group blood pressure medicines that are affected by grapefruit.
there are certain medications which are for the Blood Pressure but some that are for othr conditions that tell you not to eat or drink grapefruit juice with these medications, Be sure to ask your doctor if you are put on a specific medication if it will have side effects with any foods or drinks, better safe than sorry] We care and are willing to help in any way possible if you need further information
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