Unfortunately, it is possible for an antidepressant to stop working after being on for many years. I generally have to change my antidepressant every 5 or so years.
Please, discuss with your prescribing doctor any problems you are having and let him/her decide if you need to change antidepressants.
I think sometimes after you take medications for a long time they tend to loose their effectiveness as a example people with livers that are healthy get rid of medication it's just a normal process, its like detoxification of the liver, I am on medication for chronic pain once I am on a certain one about every year and a half to 2 years if I am fortunate the doctor has to make a change my pain is no longer under control and I think that the same thing happens with other drugs, I hope you find a drug that will work well for you
Hi , I too have benn on effexor for many years and now the doctor is weening me off. It has been very hard but Iam glad I am doing it. I have been in therapy for a few months and I find that has been helping me more. I guess in time certain medications can stop working if you are them a long time. I was on 225mg a day and now I am down to 37.5 and I can see I think a lot better then before. I am not saying that this is for everyone I can only say how I feel. I do get some depression and anxity and the horrible panic attacks but I have the xanax for that. I now have a part time job and I still can't be around crowds and a lot of stress but I am better then I was a few years ago. Talk to your doctor and ask him if you should come off and go on something else. Please do not attempt this on your own. The side effects are bad but I got through them with the help of my doctor and my therapist. Good luck to you and take good care of yourself. I am here if you need to talk.
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