I have been on premarin for 28 years and caught a bad case of anxiety:) and now on klonopin. no sex drive and very dry. The dr. put me on estratest and have a headache and very nervous or anxious I should say every day along with stomach pain. I also have acid reflux terribly bad for years now. I had a mammogram amd they found something but went in and biopsy it and it was not cancer. Now my question is which is the best hormone replacement premarin or eastratest in your opinion, thanks and God Bless p..s. I have only been on my eastratest H.s for about a week. thanks