... I will begin taking it after I finishh my premarin that I have left for it was pretty expensive. Will there be a major change like starting over again with the hot flashes and allor should it just kick in since Ive been on hormone therapy. Another question I have is that last year i started having anxiety attacks that I take .5 klonopin twice a day andheard that maybe my hormones good be the cause of my anxiety. Ever heard of that ? I really dont want to add to my anxiety right now so would like your opinion. I have studied alot on anxiety and realize that its a mind game that I have to control so I do better some days:) Thank you for your opinion. Have a blessed day!!!