... and when I removed the patch, a big red rectangle underneath. I informed my pain doc's nurse. She said the drug rep instructed me to spray a layer of benadryl before placing a new patch. Isn't this contradictory to all the directions for Butrans. This week I have Been suffering because the patch caused welts,redness, leading me to call docs office, now I sprayed benadryl and feel like I dont have adequate pain control and feeling withdrawal symptoms. Has anyone had a similar experience? I have always been compliant w/my doc, but I'm in school and working and can't take this anymore. Some nights I can't sleep cuz I'm itching all over! The second month when titrated up to 10mcg I really noticed a difference and felt Awesome!!! Any advice would be appreciated