... much good about effexor... any comments?
Most anti-depressants, SSRIs SNRIs, or even NDRIs, (and many other common and important drugs) are either inhibitors of or substrates of CYP 2D6 required for metabolism of tamoxifen and are now contraindicated during tamoxifen protocol. This website does not provide info about cytochrome metabolism but you may supplement the interaction checker here by googling each and every medication you take by "name" with "CYP 450." In many situations competition for an enzyme does not much impair the efficacy of competing drugs. With tamoxifen it matters a great deal.
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