It certainly needs to be considered.
Because of changes in the acidic environment and the reduced surface area available for drug absorption, changes in drug delivery route or dose may be necessary to assure adequate drug concentrations.
Avoiding extended-release formulations is recommended, due to their long absorptive phase in the intestine. Immediate-release formulations with a more frequent dosing schedule may be required. It may be useful to use a liquid formulation to eliminate the drug absorption phase where possible. Other routes, such as intramuscular, transdermal, subcutaneous, and inhalation, may be considered.
Talk to your doctor if you are concerned.
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