Checked on the Interactions Checker it needs to be closely monitored:
Applies to: ibuprofen, methotrexate
MONITOR CLOSELY: Coadministration with nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the plasma concentrations and toxicities of methotrexate.
Read more: https://www.drugs.com/interactions-check.php?drug_list=1310-0,1590-0#ixzz0qzFlJDbP, hope this helps?
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Methotrexate - I currently take 25MG in the MXT shot every week. I am currently 5 days late from my?
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