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I am doing a project in school and I need to know the origin of Valium. Can somebody help me?

Responses (1)

Rajive Goel 26 Oct 2010

Origin of the substance

Synthetic:
A method for the synthesis of diazepam has been described (Sternbach et al, 1961). Benzoyl chloride reacts with p-chloroaniline to produce 2-amino-5-chlorobenzophenone. This is converted to the oxime with hydroxylamine. After cyclization with chloroacetyl chloride and ring enlargement with alkali treatment, 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one-oxide is reduced and methylated to diazepam.

Copied the info from the web-site, hope it helps?

oxyaaron 23 Nov 2010

Nice! i just asked a similiar questionand got it answered

Rajive Goel 23 Nov 2010

Thanks

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