Primary prevention of tardive dyskinesia is achieved by using the lowest effective dose of a neuroleptic for the shortest time (Although, with diseases of chronic psychosis such as schizophrenia, this strategy must be balanced with the fact that increased dosages of neuroleptics are more beneficial in preventing recurrence of psychosis). If tardive dyskinesia is diagnosed, the causative drug should be discontinued. Tardive dyskinesia may persist after withdrawal of the drug for months, years or even permanently.
The dopamine-depleting drug tetrabenazine has been used to treat tardive dyskinesia and other movement disorders.
Zofran has shown some benefit in experimental studies on tardive dyskinesia and a variety of anti-Parkinsonian medications are used such as Aricept, Baclofen, Requip and Mirapex. Clonidine is used for dystonic spasms and can be of help. Botox injections are used for minor focal dystonia, but not in more advanced tardive dyskinesia. A review paper found Benzodiazepines[N 3] to be effective in alleviating the symptoms of tardive dyskinesia. However, like most anticonvulsants, benzodiazepines may cause tremors as well as benzodiazepine withdrawal syndrome upon rapid discontinuation.
In males, the branched-chain amino acid formula Tarvil, containing the amino acids valine, isoleucine, and leucine in a 3:3:4 ratio was reported as beneficial for motor symptoms in a small, non-blinded study.
However, a doc would be the best person to advice treatment, take care.
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