... around here, so surgeon put me on 100mg of synthroid. Still tired after 3 weeks, I uped my dose to 150. Going on 4 weeks now and I'm irritable and feel like a fat slug. I'm getting depressed. I've always worked out , and have no desire to do anything much less go to the gym. Ive gained weight not sure how much, but ALL of my clothes are tight and my face looks swollen. :( I'm miserable! Going to my FP Tom and asking her to add Cytomel. Does anyone have any experience with this add on TX to synthroid? Please help!!!