My brother is taking bumetanide- 1mg twice daily and is experiencing many side effects. His symptoms are: leg cramping, severe throat constriction, headache, chest pain, jaw pain, and shortness of breath. The side effects say you can develop hyponatremia, hypokalemia, hypochloremia, and hyperuricemia if you have renal insufficiency. Since he has taken insulin for several years, I assume he has renal insufficiency. Are these symptoms of hyponatremia, hypokalemia, hypochloremia, and hyperuricemia and could Bumetanide be causing these symptoms?