It's not a good idea to give both hydroxyzine and Benadryl together, to children.
Benadryl (diphenhydramine) and hydroxyzine have a moderate drug-drug interaction, but may affect children more. It is recommended to monitor the person if both of these have to be given together.
MONITOR: Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) may have additive effects when used in combination. Excessive parasympatholytic effects may result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention, and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotype, and seizures. Central nervous system-depressant effects may also be additively or synergistically increased when these agents are combined, especially in elderly or debilitated patients. Use of neuroleptics in combination with other neuroleptics or anticholinergic agents may increase the risk of tardive dyskinesia.
- Hydroxyzine Information for Consumers
- Hydroxyzine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Hydroxyzine (detailed)
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