500 mg is a small dosage. Each person is different, but I was on 1500 mg for several years without any major side affects. It was difficult to separate the minor side affects from the Hydroxyurea and the disease. I had intestinal issues, but not all the time. This drug kept my spleen in check for 15 years, and for that, I am blessed. I hope this helps you! Any other concerns or questions don't hesitate to to post.
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