I see this is a fairly small group, but wonder if any of the members have had skin problems? Or poor circulation in the toes and feet. Doctors are trying to diagnose a mysterious problem in my toes. My feeling is that it could be related to PV and Hydroxyurea (six years). They study a biopsy taken and cannot come up with a diagnosis, other than an auto immune disorder. I found one case that looks like mine that healed after stopping the Hydroxyurea. Of course that means switching to another drug and that is a huge decision. But, by not trying that first, the real danger is that this painful situation will spread to other parts of my body. A predicament! So will continue searching anywhere I can. Thanks.