Hydrocodone 10/650... non extended reléase helped my pain about 70%. Not enough to carry on my house hold duties . So my doc changed me to Oxycodone10/325, also NON EXTENDED RELEASE. IT GIVES ME ABSOLUTELY NO RELIEF AT ALL!!! I feel like I have just taken a piece of candy. I even waited an extra hour then took a second pill. ABSOLUTELY NO HELP AT ALL! What is going on here? I complained again and he changed me to extended release 30mg morphine. STILL NO PAIN RELIEF! PLEASE TELL ME WHY MY BACK PAIN ISNT GOING AWAY A SMALL PERCENTAGE!!! at least on the hydrocodone I got more relief. Is there such a thing where a person can be immune to a drug and if so. what do i do?