I am not happy with the result. He has changed. He sleeps 12 hrs a night, but tires easily, he has tremors in his r hand, and has developed a hole in his vision in one eye. He is 73 yrs, but, apart from the colitis which, with my care, was improving since we married 10 years ago, he was active, lively and happy and certainly not suffering from depression in the normal sense of the word until he started 3 years ago taking Defynol. Now everything is an effort.