I began taking Amitiza at the suggestion if my PCP. I've always had the constipation/diarrhea cycle for as long as I can remember; I've become so immune to not having BM's that I went 10+ days without BM. I've taken Miralax on a regular basis but it took 2 doses of magnesium citrate, 2 fleet enemas and 2 soap enemas before having a BM. I was originally prescribed 24 mg 2x daily but developed hands and feet. I went down to 8 mg with no success so I began taking 24 mg again. The first few days, I had almost nonstop BM's and while not diarrhea it was very soft. This went on for 2-3 days and became firmer and less frequent. However, it has been 3 days now without BM, although drinking lots of water, eating similar foods and have used Miralax in the past 2 days, still with no results. Has anyone experienced similar conditions and if so what changed the outcome?