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How to use lactulose in patient with hepatic encephalopathy?

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robo 20 Sep 2009

Dosage and Administration for lactulose

Constipation (Chronulac, Constilac, Duphalac)
Adults: PO 15 to 30 mL (10 to 20 g lactulose) daily; may increase to 60 mL/day.

Portal-Systemic Encephalopathy (Cephulac, Cholac, Enulose)
Adults: PO 30 to 45 mL 3 to 4 times daily. Adjust dosage to produce 2 to 3 soft stools/day. Hourly doses of 30 to 45 mL may be used for rapid laxation initially; once achieved, reduce to recommended daily dose. PR 300 mL with 700 mL water or physiologic saline solution via rectal balloon catheter; retain for 30 to 60 min. May repeat every 4 to 6 h.

Older Children and Adolescents: PO 40 to 90 mL/day in divided doses to produce 2 to 3 soft stools/day.

Infants: PO 2.5 to 10 mL/day in divided doses to produce 2 to 3 soft stools/day.

General Advice
Mix with fruit juice, water, or milk to make oral solution more palatable.

see https://www.drugs.com/ppa/lactulose.html

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